|
KMID : 0854720100300040314
|
|
Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 4 p.314 ~ p.319
|
|
|
A Case of Churg-Strauss Syndrome with Diffuse Trachea-bronchial Involvement and Left Ventricular Thrombus
|
|
Na Sun-Young
Jeon Soo-Yeon
Kim Yu-Jin
Park Jung-Woong
Jeong Sung-Hwan
Lee Sang-Pyo
Sung Yon-Mi
Park Sang-Hui
|
|
|
Abstract
|
|
|
|
Churg-Strauss syndrome is a rare syndrome that is characterized by hypereosinophilic systemic necrotizing vasculitis affecting small- to medium-sized arteries and veins. The manifestations of multiple tracheobronchial mucosal lesion and thrombus of left ventricle are rarely reported in Churg-Strauss syndrome. We report a case of Churg-Strauss syndrome with diffuse tracheobronchial mucosal lesions in a 52-year-old man who developed a left ventricular thrombus after discontinuation of treatment. Bronchial asthma, rhinosinusitis, peripheral eosinophilia, p-ANCA positive, eosinophilic lung infiltration, vasculitis led to a diagnosis of Churg-Strauss syndrome. On bronchoscopic evaluation, diffuse necrotizing mucosal lesions were observed on tracheobronchial tree. With methylprednisolone (125 mg/day), his asthmatic symptoms were well-controlled and eosinophil count and eosinophil cationic protein concentration in peripheral blood maintained in normal ranges over a 20 month period, but he was lost to follow-up. After 12 months from discontinuation of treatment he readmitted with relapsed Churg-Strauss syndrome with left ventricular thrombus. The thrombus gradually disappeared after prednisolone (1 mg/kg/day) and warfarin treatment.
|
|
|
KEYWORD
|
|
|
Churg-Strauss syndrome, Eosinophilia, Tracheo-bronchial involvement, thrombus, Asthma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|